Research


 

Main line of research:

Neuroengineering for the treatment of Epilepsy

Some ongoing projects according to field:

Neuroengineering

  • Nonperiodic scale-free electrical stimulation (NPS) to suppress ictogenesis and epileptogenesis: efficacy, parameters, and mechanisms
  • NPS as a means to treat motor symptoms in animal models of Parkinson's disease
  • Evaluation of neural function of animals submitted to temporally unstructured electrical stimulation
  • Usage of brain-computer interfaces (BCI) to assess student's attention in the classroom

Biomedical engineering

Neuroscience

  • Architecture of the sleep-wake cycle of animals submitted to models of seizures and Temporal Lobe Epilepsy
  • Mnemonic role of sleep (as a collaborator of Prof. Dr. Sidarta Ribeiro - ICe / UFRN)
  • Mechanisms of the endocannabinoid systems in the suppression of seizures (as a collaborator of NNC/UFMG)

 

PUBLICATIONS

Citation: Cota, VR; COTA, V; Cota, Vinícius Rosa; Cota, V. R.; COTA, VINÍCIUS R.
ORCID: 0000-0002-2338-5949 / Scopus Author ID: 14324469500 / ResearcherID: F-1752-2018
  1. Réboli, L.A.; Maciel, R.M.; de Oliveria, J.C.; Moraes, M.F.D.; Tilelli, C.Q.; Cota, V.R. Persistence of neural function in animals submitted to seizure-suppressing scale-free nonperiodic electrical stimulation applied to the amygdala. Behavioural Brain Research (Accepted), 2022
  2. Tsukahara, V.H.B.; Oliveira Jr., J.N.; Barth, V.N.O.; de Oliveira, J.C.; Cota, V.R.; Maciel, C.D. Data-Driven Network Dynamical Model of Rat Brain During Acute Ictogenesis. Frontiers in Neural Circuits (Accepted), 2022
  3. Oliveira, J.P.; Discacciati, V.; Medeiros, D.C.; Moraes, M.F.D.; Pereira, G.S.; França, K.L.; Cota, V.R. In silico investigation of the effects of distinct temporal patterns of electrical stimulation to the amygdala using a network of Izhikevich neurons. Communications in Computer and Information Science, vol. 1519. 1ed.: Springer International Publishing (Accepted) 2022.
  4. Terra, H.B.; Borges, F.; Moraes, M.F.D.; Cota, V.R. Implementation of intra and extracellular nonperiodic scale-free stimulation in silico for the Neuron platform. Communications in Computer and Information Science, vol. 1519. 1ed.: Springer International Publishing (Accepted) 2022.
  5. Santos, M.L.; Nolasco, J.D.; Cota, V.R. A multiplatform output stage for the development of current-fixed electrical stimulators applied to neural electrophysiology. Communications in Computer and Information Science, vol. 1519. 1ed.: Springer International Publishing (Accepted) 2022.
  6. Vasconcelos, N.M.; Pereira, L.A.; Silva, R.S.R.; Dias, K.S.S.A.; Mourão, T.S.; Pereira, L.C.; Cota, V.R.; Pinto, F.C.M.; Damázio, L.C.M. High Intensity Physical Exercise before the Brain Ischemia Promotes Increase in Brain Injury. Journal of Stroke & Cerebrovascular Diseases, v. 30, p. 106148, 2021.
  7. Tsukahara, Victor H. B. ; Oliveira, J.C. ; Cota, V. R. ; Maciel, C.D. . Survival analysis of nonperiodic stimulation (NPS) performance. EPILEPSY & BEHAVIOR, 2021, v. 122. https://doi.org/10.1016/j.yebeh.2021.108166
  8. Santos, M. L. ; Zacharias, L. R. ; Cota, V. R. . Open-source hardware to face COVID-19 pandemic: the need to do more and better. RESEARCH ON BIOMEDICAL ENGINEERING, v. SI, p. 1-12, 2021. https://doi.org/10.1007/s42600-020-00123-2
  9. Medeiros, D. C. ; Cota, V. R. ; Oliveira, A.C.P. ; Moreira, F.A. ; Moraes, MFD . The endocannabinoid system activation as a neural network desynchronizing mediator for seizure suppression. Frontiers in Behavioral Neuroscience, v. 14, p. 1-10, 2020. https://doi.org/10.3389/fnbeh.2020.603245
  10. Cota, V. R.; Aguiar, C.L. ; Benegas, M. ; de Souza Neto, B. . Open-source hardware as a model of technological innovation and academic entrepreneurship. Innovation & Management Review, v. 17, p. 177-195, 2020. https://doi.org/10.1108/INMR-06-2018-0036
  11. TSUKAHARA, VICTOR ; JERONYMO, PEDRO ; CARLA DE OLIVEIRA, JASIARA ; COTA, VINICIUS ; MACIEL, CARLOS . Delayed Mutual Information to Develop Functional Analysis on Epileptic Signals. In: 13th International Conference on Bioinspired Systems and Signal Processing, 2020, Valletta. Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies, 2020. p. 89.  DOI: 10.5220/0008974900890097
  12. Cota, V. R.; Oliveira, J. C.; Damázio, L. C. M.; Moraes, M. F. D. Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights. Epilepsy & Behavior. 2019, v. 121. https://doi.org/10.1016/j.yebeh.2019.106609
  13. Moraes, MFD ; Medeiros, D. C. ; Mourão, F. G. ; Cançado, S. ; Cota, V. R. . Epilepsy as a dynamical system, a most needed paradigm shift in epileptology. EPILEPSY & BEHAVIOR, p. 106838, 2019, v. 121. https://doi.org/10.1016/j.yebeh.2019.106838
  14. Tilelli, C.Q. ; Flôres, L.R.; Cota, V.R. ; Castro, O.W.; Garcia-Cairasco, N. Amygdaloid complex anatomopathological findings in animal models of status epilepticus. EPILEPSY & BEHAVIOR, v. SI, p. 106831, 2019. https://doi.org/10.1016/j.yebeh.2019.106831
  15. Oliveira, J. C.; Drabowski, B. M. B.; Rodrigues, S. M. F. A.; Maciel, R. M.; Moraes, M. F. D.; Cota, V.R. Seizure suppression by asynchronous non-periodic electrical stimulation of the amygdala is partially mediated by indirect desynchronization from nucleus accumbens. Epilepsy Research. v. 154, p. 107-115, 2019. https://doi.org/10.1016/j.eplepsyres.2019.05.009
  16. Damázio, L. C. M.; Cândido, B. A.; Tavares, A. C. O.; Rios, J. A. V. B.; Ramos, J. A.; Dias, K. S. S. A; Cota, V. R.; Oliveira, A. Effects of high intensity training on motor performance and heart hypertrophy of rats that suffered brain ischemia after training. Brazilian Journal of Exercise Physiology and Prescription (RBPFEX), v.13, 282-289, 2019. http://www.rbpfex.com.br/index.php/rbpfex/article/view/1693
  17. Santos, Talysson M. O. ; Tsukahara, Victor H. B. ; de Oliveira, Jasiara C. ; Cota, Vinicius Rosa ; Maciel, Carlos D. . Graph Model Evolution During Epileptic Seizures: Linear Model Approach. In: Vinícius Rosa Cota; Dante Augusto Couto Barone; Diego Roberto Colombo Dias; Laila Cristina Moreira Damázio. (Org.). Communications in Computer and Information Science. 1ed.: Springer International Publishing, 2019, v. , p. 157-170. https://doi.org/10.1007/978-3-030-36636-0_12
  18. Rodrigues, Sofia M. A. F. ; de Oliveira, Jasiara C. ; Cota, Vinícius Rosa . Epileptiform Spike Detection in Electroencephalographic Recordings of Epilepsy Animal Models Using Variable Threshold. Communications in Computer and Information Science. 1ed.: Springer International Publishing, 2019, v. , p. 142-156. https://doi.org/10.1007/978-3-030-36636-0_11
  19. de Souza Silva, Wenderson ; MACIEL, RENATO M. ; Cota, Vinícius Rosa . Electrographic Spectral Signatures of Animals Submitted to Pentylenetetrazole-Induced Seizures and Treated with Bilateral Asynchronous Non-periodic Stimulation. In: Vinícius Rosa Cota; Dante Augusto Couto Barone; Diego Roberto Colombo Dias; Laila Cristina Moreira Damázio. (Org.). Communications in Computer and Information Science. 1ed.: Springer International Publishing, 2019, v. , p. 258-266. https://doi.org/10.1007/978-3-030-36636-0_19
  20. Oliveira, J.C.; Maciel, R.M.; Moraes, M.F.D.; Cota, V. R. Asynchronous, bilateral, and biphasic temporally unstructured electrical stimulation of amygdalae enhances the suppression of pentylenetetrazole-induced seizures in rats. Epilepsy Research, v. 146, p 1-8, 2018. https://doi.org/10.1016/j.eplepsyres.2018.07.009
  21. Oliveira, J.C. ; Rodrigues, S. M. A. F. ; Maciel, R.M. ; Reboli, L. A. ; Cota, V. R. . Evolução temporal do hipersincronismo fase-amplitude no modelo de crises epilépticas induzido por pentilenotetrazol. In: I Latin American Workshop on Computational Neuroscience, 2017, Porto Alegre - RS. Proceedings of the I LAWCN, 2017.
  22. Cândido, B. A. ; Gomes, B. M. ; Cota, V. R. ; Oliveira, A. ; Damázio, L. C. M. . Análise da eficácia de dois protocolos de treinamento físico no desempenho motor de ratos. REVISTA DA BIOLOGIA, v. 17, p. 6-12, 2017.
  23. Cota, V. R. ; Drabowski, B. M. B. ; Oliveira, J.C. ; Moraes, MFD . The epileptic amygdala: towards the development of a neural prosthesis by temporally coded electrical stimulation. Journal of Neuroscience Research, v. 94(6), p. 463-485, 2016. https://doi.org/10.1002/jnr.23741
  24. Cota, V. R.; Maciel, R. M. . Taking sides: a case of political ideology influence in reporting neuroscience. Revista da Biologia, v. 15, p. 74-80, 2016. DOI: 10.7594/revbio.15.01.09
  25. Blanco, W., Pereira, C. M., Cota, V. R., Souza, A.C., Rennó-Costa, C., Santos, S., Dias, G., Guerreiro, A. M. G., Tort, A.B.L., Neto, A.D., Ribeiro, S. T. G. Synaptic. Homeostasis and Restructuring across the Sleep-Wake Cycle. PLOS Computational Biology,  v. 11, p. e1004241, 2015 *SEE PRESS RELEASE HERE AND HERE - https://doi.org/10.1371/journal.pcbi.1004241
  26. Oliveira, J.C., Medeiros, D. C., Rezende, G. H. S., Moraes, MFD, Cota, V. R. - Temporally unstructured electrical stimulation to the amygdala suppresses behavioral chronic seizures of the pilocarpine animal model. Epilepsy & Behavior, v.36, p.159 - 164, 2014. https://doi.org/10.1016/j.yebeh.2014.05.005
  27. Medeiros, Daniel de Castro, Cota, Vinícius Rosa, Moraes, Márcio Flávio Dutra, Mourão, Flávio Afonso Gonçalves, Vilela, Maura Regina Silva da Páscoa, Massensini, André Ricardo - Anatomically dependent anticonvulsant properties of temporally-coded electrical stimulation. Epilepsy & Behavior (Print). , v.23, p.294 - 297, 2012. https://doi.org/10.1016/j.yebeh.2012.01.004
  28. Oliveira, J.C., Medeiros, D. C., Oliveira, R.M., Maciel, R.M., Moraes, MFD, Cota, V. R. - Influência dos parâmetros da estimulação elétrica na supressão de crises por pentilenotetrazol In: XXIII Congresso Brasileiro de Engenharia Biomédica, 2012, Porto de Galinhas, PE. - Anais do XXIII CBEB. , 2012. *AWARDED PAPER, SEE HERE
  29. Vasconcelos, N., Pantoja, J., Belchior, H., Caixeta, F. V., Faber, J., Freire, M. A. M., Cota, V. R., Anibal de Macedo, E., Laplagne, D. A., Gomes, H. M., Ribeiro, S. - Cross-modal responses in the primary visual cortex encode complex objects and correlate with tactile discrimination. Proceedings of the National Academy of Sciences of the United States of America. , v.108, p.15408 - 15413, 2011. https://doi.org/10.1073/pnas.1102780108
  30. Cota, VR, Drumond, L.E., Moraes, MFD - Brain tissue stimulator for electrophysiology and neurofeedback experimental protocols In: XXII Congresso Brasileiro de Engenharia Biomédica, 2010, Tiradentes. - Anais do XXII CBEB. , 2010.
  31. Cota, VR, Guidine, P. M., Moraes, MFD - Headstage com ganho diferencial para registro in vivo de biopotenciais livre de artefato de movimento In: XXII Congresso Brasileiro de Engenharia Biomédica, 2010, Tiradentes. - Anais do XXII CBEB. , 2010.
  32. Mesquita, Michel Bernanos Soares, de Castro Medeiros, Daniel, Cota, Vinícius Rosa, Richardson, Mark P., Williams, Steven, Moraes, Márcio Flávio Dutra - Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: An fMRI study. Progress in Biophysics and Molecular Biology. , v.105, p.109 - 118, 2011. https://doi.org/10.1016/j.pbiomolbio.2010.10.005
  33. Cota, VR, MEDEIROS, D, VILELA, M, DORETTO, M, MORAES, M - Distinct patterns of electrical stimulation of the basolateral amygdala influence pentylenetetrazole seizure outcome. Epilepsy & Behavior. , v.14, p.26 - 31, 2009. https://doi.org/10.1016/j.yebeh.2008.09.006
  34. Prado, Vania F. ; Martins-Silva, Cristina ; de Castro, Braulio M. ; Lima, Ricardo F. ; Barros, Daniela M. ; Amaral, Ernani ; Ramsey, Amy J. ; Sotnikova, Tatyana D. ; Ramirez, Maria R. ; Kim, Hyung-Gun ; Rossato, JI ; Koenen, J ; Quan, H ; Cota, VR ; Moraes, MFD ; Gomez, MV ; Guatimosim, C ; Wetsel, WC ; Kushmerick, C ; Pereira, GS ; Gainetdinov, RR ; Caron, MG ; Prado, MAM . Mice Deficient for the Vesicular Acetylcholine Transporter Are Myasthenic and Have Deficits in Object and Social Recognition. Neuron (Cambridge, Mass.), v. 51, p. 601-612, 2006. https://doi.org/10.1016/j.neuron.2006.08.005

BOOKS:

Computational Neurosciece: II Latin American Workshop on Computational Neuroscience - proceedings

 

PATENTS

  1. Cota, VR ; Moraes, MFD . Estimulação elétrica de estruturas do sistema nervoso para tratamento de epilepsias e supressão de crises epilépticas, dispositivo, controlador de dispositivo e usos. PI 0605978-3, Deposited in 12/01/2006. - Granted on July '19. See press release: https://ufmg.br/comunicacao/publicacoes/boletim/edicao/2072/perfeita-dessincronia
  2. Barroso, M. F. S. ; Cota, V. R. ; Pereira, E. B. ; Rivaroli, L. ; Félix, L. B. ; Santos, R. A. ; Goulart, A. C. ; Nolasco, J. D. . Sistema para avaliação do efeito da temperatura sobre a atividade física controlada em roedores. BR1020150266480, Deposited in 10/21/2015.

Our research is currently performed in the Laboratory of Neuroengineering and Neuroscience (LINNce), DEPEL / UFSJ . Chek it out here.

Check my full CV here: http://lattes.cnpq.br/6882402886706744